Jim,
I have done testing on the 2.5 vrs 42door. The 2.5 is just a little under the 42dr. You need to run 2.5 to the door or at least 50'. This is what I have come up with over the last year, if your at 14hgs and you run 2.0 you are going to feel a little lag time for the vacuum to get to get to max. What I have noticed is with 42dr your vac seem to be faster less restriction inside the hose so the air or vac is achieved faster, a little slower with 2.5, but the the bottom line is what your vac or relief is set at.
But 4" of 2.5 is going to do nothing for you, just run 2.0 if that is all the 2.5 your going to use.