For what is being discussed here, the diff in engines is negligible. MPG many vary by 1-3 when you have stuff in the van.
The smaller engine will work harder. That is just the way it is, always has been. You can get a smaller engine to develop more HP and torque, but it still has to work harder to get it. The 4.8 will have a higher compression ratio, hotter tune, and different ratios in the tranny to develop the HP and torque of a 6.0. That means it does work harder, and there is more wear and tear, but the new motors are so tight these days, with proper maint the lifespan should be about the same.
You have to look at where it will be driven. If you are doing a majority of city driving, consider taller rear end gears. This will allow for easier stop and go driving. 4.10 for chevys.
If you don't do a lot of stop and go, stick with the stock or highway gears, 3.73 for the chevy guys.
The biggest problem with today's engines is how they are tuned from the factory. They are tuned for the middle to low end of the spectrum driving. Torque is highly limited by the computer, mainly to save wear and tear so they can offer better warranties without upping the cost for stronger parts. Basically the computer retards the timing and fuel to prevent too much power from entering the drive line.
I have a custom tuned computer in my truck, designed for towing. 75% of the torque management has been removed, which gives me much better low end power. It's great as long as you don't abuse it.