I've been banging my head with a similar problem, but on my boat. No spark! None of the cylinders.
Replaced the coil, plugs, cap, rotor.
Pulled it to the shop today, they are 2-3 weeks out. Summer will be over by then.
How many hours on the honda?
Trace the wire back looking for shorts, Also check the boot that slips over the plug.
Check all the wired connections.